CELLSEARCH® Circulating Tumor Cell Test in metastatic breast cancer (mBC)—clinical trials and real-world case studies

Pivotal clinical trial—circulating tumor cells (CTCs) in patients with newly diagnosed mBC1, 2

Trial design

One hundred seventy-seven patients were enrolled; 83 were receiving initial therapy for mBC. Circulating tumor cells were measured at initiation of therapy and monthly thereafter for up to 6 months.1


OS of mBC Patients in Groups 1, 2, 3, and 4
  1. Hayes DF, et al. Circulating Tumor Cells at Each Follow-up Time Point during Therapy of Metastatic Breast Cancer Patients Predict Progression-Free and Overall Survival Clin Cancer Res 2006;12(14): 4218-4224.
  2. CELLSEARCH® Circulating Tumor Cell Kit (Epithelial) Instructions for Use. Menarini Silicon Biosystems Inc.